Thank you. Worked really hard on the benchmark :)
No, it's not synced. When you use CalDOM without its reactive features, it's just a wrapper around the native DOM Element (similar to jQuery).
_("button").elem === document.querySelectorAll("button")[0]
Regarding capturing events of future elements: You can achieve this by setting an event listener to the parent.
Eg:
_("body").on("click", e => { if( e.target.matches("button") ) //Do something });