Ketamine is an interesting area of research, but it’s not a good candidate for long-term or even medium-term depression treatment for the reasons described in this article:

> Second, because the effects of ketamine wear off quickly unless you continue taking it indefinitely, and continuing ketamine indefinitely is very poorly understood and makes me nervous.

To expand on this: Taking ketamine indefinitely doesn’t seem to produce the same effects, as tolerance builds over time. There are several new ketamine clinics that have popped up in my area that have drawn criticism for trying to draw patients back in for never-ending ketamine treatments with escalating doses. Ketamine may be useful to start other treatments, but it shouldn’t be the only treatment. The effects are apparently short lived.