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Brython has been around a long time, at least 7 or 8 years. While I love Python and I'm not a particularly big JS fan, I feel like if Brython didn't really make a dent before ES6 and TypeScript, then it will be really hard to do it now. Does anyone know what the biggest Brython project/app is? Can we see it in production other than a simple hello world?

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Yeah, it has been there for quite some time, but has really started getting off the ground in about mid-late 2019 which is strange, since like you mentioned, the advent of TS. But slowly a lot of interest has been brewing over it, it's growing faster than ever, and has been attracting users/contributors a LOT only since the start of last year.

https://academy.cs.cmu.edu/

This is Carnegie Mellon's academy website, running on Brython. See the Brython Wiki page on their GitHub, they got a list there.

Python was itself around for years, predating PHP by several years even, before it took off; PHP got big much quicker. Ruby was around for several years before Rails helped it take off outside of Japan. So, that doesn't mean Brython will take off now, but it does at least suggest it's possible.

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