What this means now is, for the first time, you can write Clojure code on the server, interop with legacy Java code or well-tested libraries, and then write Clojure code on the client, full stack. This, as far as I know, is a pretty big game changer since it allows you to write a full-stack web application that is part of the Java ecosystem in a single language that happens to not suck either.
Edit: To clarify, I'm sure there are other JVM lisps, and other Javascript lisps. But this is the first one that is both, I'd wager. This is important.