Personally, I really enjoy working with Clojure+ClojureScript via the Luminus framework. The Caveman framework for Common Lisp is also fun. It might be my first choice if I planned to make a web app with very little JavaScript.
"The most important two tools for system programming today are two that were not used in OS/360 development almost a decade ago. They are still not widely used, but all evidence points to their power and applicability. They are (1) high-level language and (2) interactive programming. I am convinced that only inertia and sloth prevent the universal adoption of these tools; the technical difficulties are no longer valid excuses."