Who wants to start a company or a business if the local government can arbitrarily shut down your office for several months? Who wants to live in a city that could shut down bars, restaurants, and theaters for a year. I'd rather make my own decisions based on my personal health situation. For several months a vaccinated individual and business owner could not consensually do business without a face mask. Where is the science in that?
Things might be different if there were no other options, but the US is a big place. There is a lot of competition, and life is too short to sacrifice years of your life for the whims of some bureaucrat. Ironically this is the same reason I moved to San Francisco in the first place; it was a place where diverse people and cultures had the freedom to express themselves.