It is tribalism at work. Like if one takes a nuanced opinion and says "Maybe if loads of people are not dying and there's going to be no end to COVID, we should not lockdown again and again forever" You are then "them". The irrational COVID is a hoax, anti-vaxers, and get downvoted.
Unfortunately well educated knowledgeable people are falling prey to this tribalism as well. I don't view a pandemic as at all political. There's a balance as to what amount of financial, social, and loss of liberty pain we should take versus the harm COVID 19 causes. And there should be a healthy debate about that, and opinions should change with statistics coming out and changing conditions. Meaning hardline anti-vaxers should probably soften up a bit as the vaccines have been shown to be extremely effective and safe and hardline lock down the world adherents should look at the dramatic drop in deaths and hospitalizations, and compare the risk of COVID with other risks we take in our life like driving.