Seconded. Also check out the FeatherS2, designed by the same dude: https://feathers2.io/

I actually like the FeatherS2 for one reason, which is that it presents itself as a USB storage device and you can just drop Python files into it. Easier than the `ampy` stuff you have to do with the TinyPICO, and it comes with a "Stemma" port that you can wire up most Adafruit/Sparkfun sensors to. And it has mounting holes, which are a godsend if you want to make a proper 3D printed case for your project.

The only downside is FeatherS2 is CircuitPython and TinyPICO is MicroPython, and you don't get threading on CircuitPython.