No kids here, and my wife works most weekdays as well (but out of the house, in a cubicle farm mostly answering calls so well isolated) so the first 2 points aren't a big issue for me.
- No boundaries in terms of when work ends and begins
I really struggled with this throughout last year. By the end of the year, though, I'd set up a home gym (this requires space, I have a basement rec room that was near perfect) and that became my end of day space. At 4:30pm I put on socks and gym shoes and go down there and exercise for 30-90 minutes every day (with spring and summer part of that was moved outside for running). I was no longer finding myself still at my work computer at 6pm, or turning it on at 7pm to see if I'd gotten responses to certain emails from people in other timezones. My day simply ended. It also helped to elevate my mood and reduce my anxiety as I was getting into better health.
It's still hard to do with kids, and again you have to have the space for it. But it can work very well if you can pull it off. Even just getting out for a 30-minute run or walk after work is a nice disruption to help separate the work day from the non-work day (that was my routine when I worked in the office but couldn't stop thinking and stressing about work after the work day officially ended and I went home).