Death can never be defeated - besides accidents and catastrophes, there's always entropy - but life can have some interesting twists if your life extends longer and your mind extends further.

However, I think even a few small changes to mental capacity or an extension of life expectancy beyond 2-3x will make the recipients something other than human. Our brains have many quirks that limit our ability to reason, understand, or act rationally, but those quirks are essential to our humanity and our ability to love. I think for this reason alone, few will elect to have very drastic changes made to their minds or their lives.