In the long term you could develop some best practices around killing pests.

I always thought something like Pabio for used mattresses would be great, so people could easily try lots of mattresses and find one which really helps them sleep.

To do that you'd need a nontoxic process for ensuring the mattress is free of bedbugs (e.g. put it in an airtight bag, then fill the bag with an oxygen-free mix of nitrogen+CO2 for long enough that any bugs will suffocate)