Sure. SCO/Microsoft Xenix. You could buy a PC AT or compatible clone, hang 2-4 terminals off it (the console gave you one extra) and run point of sale, physician's office management software or accounting software. Terminals cost about 1/4 of what a 286 cost in 1986-1989 so you'd see a lot of it in small businesses, and there were a few chains that used it because they could use UUCP to send in data to the home office.

Fun. Here's a link to the programmer's guide: http://www.nj7p.org/Manuals/PDFs/Intel/174391-001.pdf pages 2:17-2:22 cover the pointer and data type sizes. Amazing how little things have changed... and how different things are at the same time.