"including losses greater than the staked amount" I don't think this is true. Binance will happily liquidate you well in advance of a possible negative balance.
I was going to say, while technically there is the risk of loosing more than your stake, practically speaking you will be margin called long before that happens.
Ahh yes, I remember when people used to say that about trading in the trillion dollar a day foreign exchange markets.
Then people lost 5 times their margin in the blink of an eye.