It's way too heavy, even for the day-to-day. A tool of that sort, for which I have to close tabs when not actively in use to save resources, even on powerful machines, or where clicking a link to a ticket might take more than very-low-hundreds of milliseconds to load, is bad.
GH issues? I click a link without thinking twice, and it's open fast. Almost every interaction is quick. I can leave a dozen tabs with GH issues open for weeks and not notice. Jira? Asana? "Ugh, a list of five issue links and I don't know which I need... fuuuuuck I don't want to open all these to find the right one, should take 10s total but will take a minute or so", and "why's my whole system feel weird? Damnit, I left Jira/Asana open again, didn't I?"