This was recently on HN, seems interesting (didn't try it yet though)

https://github.com/chriskiehl/Gooey

wxPython is great.

wxPython is the best and most mature cross-platform GUI toolkit, given a number of constraints. The only reason wxPython isn't the standard Python GUI toolkit is that Tkinter was there first. -- Guido van Rossum

The official python bindings for Qt ie pyside [1]

[1] https://www.qt.io/qt-for-python

Check PyQt which provides python bindings for Qt.

Tkinter is a choice.