>refusing vaccination for mostly irrational reasons

Depending on age and condition the risk to an individual can vary from one in ten million to under one in a hundred. In your mind, what is the risk that an individual must face from covid to make it rational to take a novel treatment with no long-term safety data that hasn't passed the standard FDA approval process? In any other context, would people here be so confident that there's a less than one in ten million risk from a novel MRNA treatment?