I have used mostly default keybindings in Emacs for over a decade and what hurts my wrists the most is web applications that force me to use the mouse.
Did you ever remap any keys? Can't imagine what it would be like without setting `caps lock` as `control`.
I use Kinesis Advantage keyboards where one of the keys in each thumb cluster is control, and my capslock is Super. The latter is because Emacs is my window manager and Super is the modifier key for WM commands.
I think Emacs did permanent damage to my hands before I got a special keyboard. "Works for me, wontfix" isn't a good position to take on that kind of issue.
Get Vimium plugin, it will decrease your mouse usage
Vimium is great, the problem is complex web apps that don't use standard HTML elements (so they become invisible to Vimium).