The mechanisms of action of Ivermectin against SARS-CoV-2
nature.com
nature.com
As per data available on 16 May 2021, 100% of 36 early treatment and prophylaxis studies report positive effects (96% of all 55 studies). Of these, 26 studies show statistically significant improvements in isolation. Random effects meta-analysis with pooled effects using the most serious outcome reported 79% and 85% improvement for early treatment and prophylaxis respectively (RR 0.21 [0.11–0.37] and 0.15 [0.09–0.25]). The results were similar after exclusion based sensitivity analysis: 81% and 87% (RR 0.19 [0.14–0.26] and 0.13 [0.07–0.25]), and after restriction to 29 peer-reviewed studies: 82% and 88% (RR 0.18 [0.11–0.31] and 0.12 [0.05–0.30]). Statistically significant improvements were seen for mortality, ventilation, hospitalization, cases, and viral clearance. 100% of the 17 Randomized Controlled Trials (RCTs) for early treatment and prophylaxis report positive effects, with an estimated improvement of 73% and 83% respectively (RR 0.27 [0.18–0.41] and 0.17 [0.05–0.61]), and 93% of all 28 RCTs."
Given that, why are so many opposed to Ivermectin and why is big tech suppressing the discussion of it?
"The well-tolerated drug ivermectin may hold great potential for treatment of YFV [yellow fever virus] infections. Furthermore, structure-based optimization may result in analogues exerting potent activity against flaviviruses other than YFV." (2012)
In principle any drug can potentially be used to treat any disease. The real questions are: is there a plausible mechanism of action, and is it safe and effective in clinical trials?
Diet and exercise are known to impact COVID-19. We can focus on multiple different treatments simultaneously.
100% of the 17 Randomized Controlled Trials (RCTs) for early treatment and prophylaxis report positive effects, with an estimated improvement of 73% and 83% respectively (RR 0.27 [0.18–0.41] and 0.17 [0.05–0.61]), and 93% of all 28 RCTs. These studies are tabulated in Table 1. The probability that an ineffective treatment generated results as positive for the 55 studies to date is estimated to be 1 in 23 trillion (p = 0.000000000000043)."
Just another reminder that the sole purpose of the FDA is to juice Big Pharma profits (when it's not busy juicing the profits of big food, to further help stimulate big pharma demand)
Footnote: the reason Big Tech also conspires to block discussion of this is the massive amount of spending they receive to market the blockbuster drugs that never have much efficacy and always seem to get recalled within a few years for actually being deadly.