So to be perfectly safe, one would be ultra-paranoid and stick to games released in the 20th century and then frame it as a kind of historical landmark in the video game market: what do video games in the 20th century say about what we knew about operant conditioning up to that point?
Example: suppose a behaviorist foundation and ask questions about really minute details related to visual and motor processing. Another: observe the expected and actual effects on behavior.
Would you conduct a Stanford Prison Experiment style of experiment if it were done with video games? That is, the players are associated with guards and prisoners, and they play out similar roles that the original experiment outlined, but in a virtual world?