Covid Spike Protein Elicits Signaling in Host Cells: Implications for Vaccines

Imagine this spike protein, either from COVID or a vaccine causes a chain of events causing ones children to be infertile.

There are various environmental things that can cause offspring to be infertile, so the scenario isn't totally unreasonable.

We probably wouldn't figure that out for ~20 years.

By that point, probably 95% of earth's population will have been vaccinated or exposed.

For a newborn to be fertile, they need two non-affected parents. So the chances of that might be 0.05*0.05 = 0.0025.

What would society look like with a generation where 99.75% of people are infertile?

Luckily the chances of my hypothetical happening are nearly nil... But it's still scary!

when a spike protien is expressed as an insertion into the cytoplasmic membrane there is very limited mobility, and less potential to approach ACE2 with appropriate orientation and energy for receptor ligand-interaction to occur, this would result in somewhat less interaction of the spike with the rennin angiotensin system[RAS]. a concern would be the possible development of abberant or deletion type spike protiens translated from undesirerable spike-mRNA species, the scenario of most concern would be a spike protien with malformed or deleted transmembrane domains, thus allowing a speudo spike protien to move freely outside the host cell.

this doesnt indicate that there is an unconceived problem, this publication is recognizing that perturbations of the RAS are highly consequential; a major part of covid pathology; and a hidden gotcha, should vaccine development ever become cavalier regarding RAS signaling and spike based agents