Rather, it means: Find a career and lifestyle that is intellectually and emotionally fulfilling and make the best of it.
I understand that there might be other complications like family, people dependant on you etc. But it all boils down to what you love and how much you love.
"Do what you love" might be better put: Make your money doing something related to what you're most passionate about.
So if you're into sex, coffee, reading, writing and travelling - write a hedonists travelling blog while you're doing it. Or move to Costa Rica and open an online boutique store where you sell only the finest local coffee to other aficionados. Or coffee and books about sex. Or create a community site (see Ravelry) where people who share your passions can mingle.
I think the idea is that doing something that feeds your passion is a reward in of itself. And because you're passionate about it you will enjoy to putting more effort in and thus have greater chance being successful.