Meaningful to one's self and principles. In the sense that Viktor Frankl wrote about in "Man's Search for Meaning." Wherein he describes the survivors of the nazi concentration camps were the prisoners who had something personally meaningful to live for. People thrive if they have meaning in their lives.

If you can derive meaning from your career, that's great. Otherwise, family or contributing to society or whatever you think makes a difference in the world and is worth working toward.

Like everything, gaming is great in moderation, but the gamer who does nothing with their life but game is probably going to have some regrets on their deathbed.