First hit on Google for '"indian reservation" pycon' points to a Reddit page which points to https://www.youtube.com/watch?v=bSfe5M_zG2s , which must be it
That is likely it. Keynote speech Pycon 2016.
Will check it out shortly.
Edit: Yeah, this is it. It's incredible. I didn't remember most of it because it's a lot of math, music and programming that's over my head.
Thank you very much.