Yes but disabling JS as a default wipes out whole classes of attacks against your browser.

On top of disabling JS, just a simple AD blocker like uBlock Origin greatly diminishes the amount of profiling. There is no silver bullet however. It depends on your threat model.

If you really don't want to be tracked and profiled, using the Tor Browser Bundle is worthwhile, but even that is problematic since it's heavily surveilled (both at the entry node and exit nodes).