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Comment by shkkmo | Hacker News Reader

My understanding is that the current vaccine helps against all strains, but also makes the infection worse if you do still happen to catch Dengue (similar to a previous infection.) As a result this risk is managed by only giving the current vaccine to people who have already had Dengue atleast once

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To clarify a bit, if you've already had dengue once, the vaccine is recommended since it makes you less likely to catch the other strains of dengue and it reduces the odds of severe complications.

However, if you've never had dengue, the vaccine is not recommended since it increases the odds of complications.

This rather odd effect is known as antibody-dependent enhancement: https://en.wikipedia.org/wiki/Antibody-dependent_enhancement

I had dengue once and got vaccinated afterward, since I live in a dengue hotspot. However, not many do, the cost and complexity (~$300 for 3 shots over 18 months, generally not covered by insurance) also dissuades many.

Hiya - I don't live in a dengue hotspot country but have had it (grandparent lives in a tropical country) and would like to get Dengvaxia to make it a bit less risky to go back... do you know if your country would allow flying in to get the vaccine? May I ask which country it is?

Thanks!!

I'm pretty sure you can just go up to a pharmacy here in Costa Rica and get it for about 140$ - if you want I can confirm for you

https://www.nacion.com/ciencia/salud/vacuna-contra-el-dengue...

Hi yes please that would be amazing! Some of my family is in the US so it wouldn't be too hard to drop by on the way there :)

You want to try Farmacias Sucre out here for vaccines (I think they were the only ones I could find who did the yellow fever one), although maybe the best way to take it would be seeing a doctor to get a prescription after checking your antibody levels. Most pharmacies here have a general practitioner in there who maybe even owns the place for consultation... just look for the person in the white jacket. Chances are their English is fine. Also looks like Clinica Biblica has it for only about 88$, they're alright:

https://alivioexpress.com/inicio/esp/detalle-producto.php?pr...

Fantastic, thank you!

What happens if one gets Dengue for the first time after only one dose of Dengvaxia.. not the complete scheme? Will it be as bad (complications-wise) as having the complete vaccination scheme?

You should absolutely *avoid* using this vaccine _unless_ you have been previously (and provably) infected by one of the strains of dengue. Unless you want to actually *increase* your risk of doing a hemorrhagic form. Seriously don't do it, people have died over it.

What happens in the scenario in which someone hypothetically got the first dose but didn't finish the vaccination scheme?

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