Does anybody have any ideas as to what this means for people who've had COVID and then get vaccinated with one of the mRNA vaccines?
If not, is anyone studying this?
If not, is anyone studying this?
I'm more interested that this means that quite likely, COVID-19 will be eradicated: with not many advantageous mutation pathways, and if vaccines are conferring immunity forever, it's pretty much going to be burned out of the population one way or the other.
I was under the impression that any mutations to the spike proteins would make the current vaccines useless and would require changes to the vaccines just like the flu shot . Isn't this the case ?
No, it is not the case.
You don't just make one antibody that targets the entire spike that would be thrown off by a mutation.
>Human Antibodies Target Many Parts of Coronavirus Spike Protein
https://directorsblog.nih.gov/2021/05/18/human-antibodies-ta...
So far, all the claims that a variant (London variant, South African variant, Indian variant) would be immune to the current vaccine have turned out to be unwarranted.
There are countries that are yet to achieve even 1% and some populations are likely to never achieve the threshold for immunity in that population.
I expect having stronger flu-like side-effects on the first injection instead of the usual second mRNA injection. For this reason, if you had diagnosed COVID, in France you'll be injected a single dose of mRNA vaccine and be considered immune.
> Ellebedy’s team has observed early signs that Pfizer’s mRNA vaccine should trigger the production of the same cells. But the persistence of antibody production, whether elicited by vaccination or infection, does not ensure long-lasting immunity to COVID-19. The ability of some emerging SARS-CoV-2 variants to blunt the protective effects of antibodies means that additional immunizations may be needed to restore levels, says Ellebedy. “My presumption is we will need a booster.”
The idea seems to be that an infection is like a single dose of the vaccine, so you still need another shot for the best immunity.
>People who have already had confirmed covid-19 might only need a single dose of a mRNA vaccine, two small studies have indicated.
Two weeks after a single dose of vaccine, people who had previously had covid-19 had antibody concentrations that were as high, or up to 10 times higher, than the levels seen in uninfected people who had received two doses of the vaccine.
"Since then, one study after another has reinforced the single-vaccine-for-survivors idea, though some skeptics have pointed out that it is logistically simpler to just give everyone two doses than to figure out who needs only one...Cheng at Cedars-Sinai said she would still default to the CDC guidance calling for two vaccines, even for people who have had COVID-19. The data does suggest, however, that one dose could be enough"
https://www.japantimes.co.jp/news/2021/04/18/world/coronavir...
The days after that I felt much worse that when I had the actual infection, albeit for a shorter time, so I personally would appreciate an official recommendation to not have to take the second dose.
I would have happily skipped the second Pfizer shot if the CDC said it was ok.
In a nutshell - covid patients have sustained antibodies, non covid with vaccine groups have faster decay from Peak concentration.