If you'll look carefully, you'll see that's a non peer-reviewed opinion piece.
That's a prime example of disinformation, and indeed the most reputable journals unfortunately play a role in it.
Just to rebut the first thing random thing I saw:
"An important controversial point to consider in any rationale is the 5 µM required concentration to reach the anti-SARS-CoV-2 action of ivermectin observed in vitro,17 which is much higher than 0.28 µM, the maximum reported plasma concentration achieved in vivo with a dose of approximately 1700 µg/kg (about nine times the FDA-approved dosification)"
They are bringing up the in-vitro studies initially done on monkey kidney cells, and then claiming that you'll need such a high dose in a clinical setting. The doses for prophylactic and early treatment are an order of magnitude lower (0.2mg/kg) [1], and in that dose it's safer than paracetamol.
"Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA-approved dose of 0.2mg/kg." [2]
In my second link, there's a talk rebutting the in-vitro safety concerns in detail: [3]
There are over 50 studies showing that Ivermectin is effective, and more are coming in every day. [4]
1. https://covid19criticalcare.com/covid-19-protocols/i-mask-pl...
2. https://pubmed.ncbi.nlm.nih.gov/12362927/
3. https://player.vimeo.com/video/554350476?autoplay=1#t=4702
4. https://c19ivermectin.com/