Since I saw the "replace the entire stack" image, I expect no less than that the website should be made in Beads, hosted on a server running Beads OS, and the frontend should be WebAssembly compiled from Beads.
But any day now the dam will break, and WebAssembly will get access to I/O and the full browser API (last time i checked web assembly runs on its own compute-only thread, and is not permitted direct access)
Portable generic VM (like the jvm but for anything), sure why not.
Having web browsers allow arbitrary access to hard disk? That's something else.