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Comment by axiak | Hacker News Reader

this paper is discussing mechanisms limited to the J&J and Astrazeneca vaccines

Are the mechanisms limited to those, or did they only investigate the proteins specific to those vaccines? My understanding is that they only looked at the spike proteins for those vaccines and did not evaluate the others. My understanding is that the proteins in the others have the potential to interact similarly with the ACE2 mechanism but were not evaluated.

The issue seems to be with the DNA -> mRNA transcription required by the adenovirus vector of the J&J and AstraZeneca vaccines, leading to mutated spike proteins which can cause clots. The Pfizer/Moderna shots don't use this mechanism so weren't the subject of the paper.

(This is not my specialty at all, just summarizing the abstract & what other commenters wrote since nobody replied to you yet)

I'm sorry about your father-in-law.

Oh, I see. So similar mutations don't occur with straight mRNA. I think that makes sense. But also I thought the exact spike protein structure could vary with mRNA vaccines too based on the patient's genetic make up because the mRNA only encodes a portion of the spike and the rest of the spike is generated by the host cell.

I don't know, that not my area either. My main two points are that if covid itself can increase risk of stroke and now some covid vaccines can too, then I wonder if other covid vaccines might have contributed to this anecdotal one. The second point plays into the first. I would be less likely to question it if we had better reporting in the VAERS system.

He actually seems fine now, so he recovered quickly.

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