Analysis of blood markers predicts human lifespan limit
nature.com
nature.com
- David Sinclair Why We Age and Why We Don't Have To. Mostly focused on NAD+, sirtuins, use of yamanaka factors to reset epigenetic clock
- Horvath for horvath clock using dna methylation to measure aging in organisms.
- Michael Lustgarten a good curator for biomarker related research for longevity
- Rhonda Patrick has insightful scientific interviews and dietary and behavioral interventions
There's a spreadsheet with 9 biomarkers (with correlations) and age for Levine's Phenotypic Age floating around, based off this paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111/
Many I've discovered through this podcast, which features a number of people on the above list as guests: https://peterattiamd.com/podcast/
He becomes a different person when he has taken his vitamins for the day, a more caring person. It's been a profound transition, and one that we didn't expect. We had tried everything - improving sleep, improving diet, weekly behavioral therapy. Nothing has come remotely close to the impact that the Niacin/Magnesium combination. It's probably a 70% improvement in behavior. That dramatic.
I stumbled across the works of Abram Hoffer. That this is probably an issue related to overmethylation within his system, and the B3 helps subside this issue. At least my very basic understanding. I know I am trivializing the domain - I don't mean to.
Not sure how to confirm that overmethylation is the issue, hence why I was asking. Thanks for the insight.
P.S. For those curious, this is the current protocol of vitamins we have been using to help him.
https://aantix.medium.com/my-son-niacin-magnesium-and-the-tr...
Thank you for sharing your specific protocol by the way, I was about to ask. I've tried Magtein before but nothing like the doses you describe, and never paired with Niacin
l-threonate is much lower dose of elemental magnesium, usually 144mg, but it's much more targeted.
*Edit: Added a mistakenly omitted word.
There could be a treatment that we've completely missed.
Secure an appointment in a genetics clinic at a world-leading institution - think the sorts of hospitals that routinely see the rarest genetic diseases in the world, CHOP, CHLA, Rady in SD, Emory, Children's Boston, Lourie in Chicago (the children's hospital, not the cancer center), Nationwide in Columbus, Hopkins, etc. Ideally you'd be seeing someone who is continually identifying and publishing newly discovered genetic diseases.
Compose a short, concise document detailing developmental milestones as well as symptoms. Include all interventions that you have found to work and not work. Include all prior test and imaging results. This document will be given to the geneticist and genetic counselors you meet with. You can also look into having the medical record transferred over from the primary care facility to the geneticist's office.
Let them handle the rest. They may recommend testing, they may recommend consults with additional specialists, they may feel the issue is not genetic. It is important to keep in mind that one does not need to be far outside of the box to butt up against the limits of medical knowledge. It is possible that this strategy may not help. There are also research programs, such as the undiagnosed disease program at the NIH, that may also be potential avenues to pursue. It is also possible that the issue does not have an identifiable genetic cause, or if there is, the underlying pathology is currently not understood.
Good luck.
https://www.illumina.com/techniques/popular-applications/epi...
I am just wondering about my capability to interpret it correctly within the context of my son's symptoms. I wouldn't want to wrongly diagnose him.
The field of longevity influencers has exploded recently, with increasingly confident claims extrapolated from preliminary research and hypotheses.
Some of the longevity influencers, including some of the people in the list above, have significant financial interests in promoting their theories and methods. This ranges from selling educational materials to speaking engagements and even promoting supplements. As is typical with cutting edge research, the confidence of certain claims tends to be exaggerated when a financial conflict of interest becomes involved.
A few years ago the longevity world was all about resveratrol after some promising early research, though later research suggests that resveratrol isn’t quite as miraculous as it was initially promoted. We’re currently going through a similar cycle with NR/NMN supplements like Niagen.
There may be some promising developments in this area, but I wouldn’t rush out to spend money on expensive supplements that haven’t been tested at high doses long term in humans just yet. Longevity influencers like to talk about the potential upsides, but they rarely admit the unknown potential downsides.
If we want to take aging seriously, we need to first appreciate the problem. It reminds me how people used to think there was "the cure" for cancer.
We've absolutely been here before with vitamins, both the fact that they're simple molecules and part where we over-promise what they can do. (Example: vitamin C mega-dosing)
I wouldn't be surprised there's a few "One Weird Trick to Extend Your Life by Five Years"s yet to be found, but to solve aging I expect to be much harder. It wouldn't surprise me much that the simplest "solution" to aging could end up being the brain simulation thing anyhow, because fixing up the biological organism across hundreds of years is simply that hard.
If there are a few of those weird tricks I definitely expect a period of excessive optimism where people conclude we're just another couple of such tricks away from the solution, when instead they are simply the first steps on a very long path.
The latter is probably closer. We can already induce extended periods of apoxyia in animals by replacing blood with cold saline without brain damage so a similar procedure should be possible to keep healthy brain tissue intact while scanning it. The necessary fidelity of the simulation is what we don't know yet.
Keeping a human being alive for 500 years means knowing how to do roughly the same thing to bodies in order to accomplish the major periodic surgeries necessary to replace failing/injured parts including healing the brain itself, so probably represents a harder technical threshold.
That happens every night I go to sleep and a fair portion of my atoms get swapped out by normal metabolic processes. My neural network changes as I'm unconscious or dream. I don't even remember all my dreams, but wake up with new thoughts/ideas sometimes.
We're always some delta from ourselves the previous day. I'm very different from the me of 10 years ago. The jump to a brain simulation may be a large change, but I could also tweak the things that didn't feel quite right or match with what I used to be like.
Resource constraints are certainly an issue; the fairest way seems like pre-allocating a subset of resources to each duplicate who in turn can do the same. Societal restrictions on creating a duplicate with too few resources would prevent effective slavery or abject poverty.
Scenario 2: Same as 1, wake up in new body, etc. But they also wake up the old body. "Hey, I thought I was going to be in a new body!" They point at the young "you" doing a happy dance. "We just wanted to show you that it worked. Congratulations. Now lie back so we can deactivate you." The other one stops his happy dance: "Let's forget about that update ten years from now."
That's a weird statement to make, while in the largest part of the 20th century, most medicinal advances were made using small molecules. Aspirin is a very potent drug that had dozens of actual applications at least, yet remains a very simple molecule.
https://peterattiamd.com/does-nmn-improve-metabolic-health-i...
Humans are exceptionally long-lived animals that live for about 4x as many heartbeats as other mammals. It is one thing for treatments to give animals some of the resilience to aging we have, it's another to extend the frontier of human lifespan.
Not everyone has the luck of being cared of as British Queen and Prince were, yet they seem to die anyway.
Looking at long life proponent Ray Kurzweil, he takes one million dollars of vitamins and supplements yearly and looks alot older than his age. He seems to be wearing a wig lately which makes him appear a bit younger but I think his supplement regime is big waste of money.
Do you happen to have a link to the spreadsheet handy too? Thank you, if so.
NR and NMN have failed to extend lifespan in rats, so it probably doesn't work with humans. (I don't know anything about yamanaka factors.
The key factor of humans getting to where we are (both good and bad), is our ability to see something that is, then figure out why it is how it is, and then change that structure/process/sequence to rearrange it to meet our goals.
I think this research is as much about to estimating the maximum age of an organism if all causes of premature death are removed. i.e. to get longer than that you need to fix aging itself not disease
So, the question becomes: what if instead of merely observing those markers, we actively remove them, or block the receptors they interact with?
[1]https://www.wired.com/story/long-strange-life-worlds-oldest-...
Limits are not defined by history, they are defined by our current understanding of science (and they are often wrong).
I remember reading in Genesis (first book of the bible) that the maximum age was limited to 120 years (chapter 6, verse 3).
Indeed, the stories of Enoch and Methuselah show that any hard bound was clearly violated within a tiny group of humans it claims are originators.
you're taking things a little literally here; that's perfectly explainable, and is also paralleled in the other mythos you mentioned: a group of people would raise their own status by claiming to be descended from gods or demi-gods or something else extraordinary. Probably the most approachable example of this in western literature is the figure of Herakles/Hercules.
it is not a stretch to imagine that the people responsible for writing certain books of the hebrew bible raised their own status by claiming to be descended from extremely long-lived ancestors.
Additionally, methusaleh's obtained age was recorded as 969 years; this should be understood not literally, but figuratively: 969 is a looooooong time, and a mystical number. It means "this is important, pay attention to this. this person is special". It helps the narrative in an oral tradition.
I don't subscribe to this view, because I no longer believe the stuff described in the Bible actually happened as described - but if I were trying to treat the Genesis stories as real, this would be the approach I'd take to reconcile them with scientific knowledge.
But I don't think there's any point trying to reconcile the naratives.
My fundamental point is that a broken clock isn't predictive, even when it happens to be right.
2000 years ago but even the King James Version wouldn’t have been using a gregorian calendar yet
And usually when talking about the Bible there has some greek or hebrew translation liberty
Before we all decide it’s open to interpretation anyway
Well I had your whole conversation for you, let me know
I don't know if there are retroactive fixes to what years were which and if that coincides with the Bible or universal acceptance of their solar calendar
Let me know
Plus the winter, which was unassigned until it eventually became January and February. I don't see anything about it counting the entire year as anything other than a solar year.
Not quite. Methuselah died in the Flood, and it was only _after_ the flood when God decreed that humans' lifespan would be limited to 120 years.
Genesis chapter 11 (allegedly) recounts the lineage of Abram. Shem (who was on the ark) lived to be 600. His son Arphaxad lived to be 438. HIS son (Shelah) died at 433. Et cetera. Abram is only eight or nine generations after the Flood, depending on how you count.
To my eye, there's a clear dampening effect on ages after the Flood. Within a dozen or so generations, mostly everybody dies before age 120.
Some of us have actually studied the Bible in depth. It has its contradictions, but IMO this isn't one of them. :)
Unless some changes were made in modern translations.
I have absolutely no evidence that any group did so, of course, but it wouldn't be totally absurd.
Source: Noah's Ark and the Ziusudra Epic: Sumerian Origins of the Flood Myth by Robert M. Best
“Notice that Sarah lived to be 127 years (Gen. 23:1), Abraham lived to 175 years (Gen. 25:7), and Jacob lived 147 years before dying (Gen. 47:28).”
https://www.neverthirsty.org/bible-qa/qa-archives/question/t...
This isn't a debate about the object level "is this story true", this is people saying "that's not what the story is".
That said the numbers in Genesis were incorrectly translated from cuneiform into Hebrew. If you translate them back into cuneiform and then forward again correctly, you get smaller numbers that match up with the ages people have children or die today.
Source: Noah's Ark and the Ziusudra Epic: Sumerian Origins of the Flood Myth by Robert M. Best