Plus: highest concentration of intelligence on the Eastern seaboard. It's pretty spectacular.
Minus:
Warning: what follows is my own opinion based on my own experience, and YMMV, but:
Coldness. People don't really connect. They don't really have friends. They don't "hang out," or if they do the conversations are either technical or about the weather. Try to talk to someone about anything emotional, or far out, or speculative, or... anything other than brainy topics or the weather... and you're very, very weird and people look at you funny and go back to the weather.
For the first two years I lived there I thought it was me. Then I had this friend who lived there... total social butterfly, way more than me. After he'd lived there for five years, he had more friends in New York than in Boston. He moved to New York. I went and visited him and after being there for three months he had like twenty friends.
The entire Boston area is cold and anti-social, especially the MIT/Harvard nexus.
Somehow I don't think the specs are going to help, because I don't think it has anything to do with social ability. I got the distinct impression that being friendly was considered a mark of low social class.