As of 1.x, Inkscape no longer uses XQuartz so, if you tried it over a year ago, it's worth trying again.
There's a long discussion about it here: https://gitlab.com/inkscape/inkscape/-/issues/1614
@je42: It becomes usable though if you Get Info on the Inkscape application in Finder and then check the "Open in Low Resolution" checkbox.
I don't think there is going to ever be much interest in getting this fixed in GTK3, but apparently performance has improved in GTK4, which should be hardware accelerated on macOS now: https://blogs.gnome.org/chergert/2020/12/15/gtk-4-got-a-new-...