> Never noticed someone trying to send a email to any addresses I haven't previously used.
At least a few years ago, I noticed a lot of spam to <random first name>@<my domain> -- i.e., completely made-up addresses that I had never used. Since messages sent to those addresses were guaranteed to be spam, I started treating them as free training data for the spam filter.
I don't know if this still happens, though, because I haven't looked.