Never.
> The [ipv6] address space therefore has 2^128 = 340,282,366,920,938,463,463,374,607,431,768,211,456 addresses
> The [ipv6] address space therefore has 2^128 = 340,282,366,920,938,463,463,374,607,431,768,211,456 addresses
That's not even counting the 65535 ports you could then use.