I just bought a little teardrop camping trailer, and it was amazing how much it impacted my gas mileage. I tow with a Subaru outback, and I went from low 20s (23/24 on highway) to mid teens. Almost ran out of gas on our first trip since it went so much faster than I expected!
I can't imagine that the F150 would be good for long haul trailers... just so much energy involved moving weight around.