Well-defined integer overflow would not preclude loop unrolling in this case. One simple alternative would be for the compiler to emit a guard, skipping unrolling in the case that (offset+16) overflows. This guard would be outside the unrolled loop. Furthermore, unsigned values are often used for indices (the unsigned-ness of size_t pushes programmers in that direction) and unsigned overflow is well-defined, so any compiler engineer implementing unrolling should be be able to emit such a guard so that the optimization can be applied to loops with unsigned indices.