I use Wipr as a content blocker on both macOS and iOS. I never see ads on YouTube. But I've always felt that it might not be enough some day. Perhaps that day is nearly here.
It was a frustrating experience, I've tried Safari multiple times over the years since it is so much better on battery life, but Chrome always wins in usability and adblocking.
I switched back to Chrome + uBlock Origin and could use those sites ad-free again. Well, except for Twitch, since they found a workaround for adblockers last year.