Even Rimuru Tempest gets superpowers (Great Sage) because he died on Earth as a 37 year old virgin. Or if anime references don't work... 40 year old virgin movies or whatever.
It seems like one of the few thing you can poke fun at without people actually getting super serious about.
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As I said elsewhere: I know there's a growing group of incels who are taking this virgin stuff very seriously. Literal violent acts because they feel like they feel like the chads are taking all of the women or whatever.
But there's a larger group of people who are just innocently joking around with this meme.
It's about context. Maybe if the incels become more popular, I'll hush up about these virgin jokes. But it hasn't really crossed my threshold quite yet.