Vitess' compatibility with MySQL has made major leaps in the past couple of versions and the team has started focusing on locking in ongoing compatibility with various popular development frameworks. You can find those here, and more are getting added regularly: https://github.com/planetscale/vitess-framework-testing/

The basics of MySQL compatibility are described in here, though it's important to keep in mind that just because something "works" doesn't always mean it's the best way to do things in a sharded environment: https://vitess.io/docs/reference/compatibility/mysql-compati...