This is commonly trotted out, and it is false for all practical purposes. The US does have a lot of empty spaces where no one lives--but no one is seriously proposing to hook up empty spaces to HSR. If you instead look at where people in the US do live, it's not all that different from those places. If you mapped out the major cities of the Midwest centered on Chicago and compared it to France, you'll find that the US has larger cities whose distances from the major regional hub are roughly the same as their corresponding cities in France. Since HSR works in France to connect those cities, it should generally work equally well in the US to connect those cities.