I'd start with the higher level question, do I want a production Python deployment and all the headaches of deploying, managing, scaling, etc. that come with it? There are some fantastic things in the Python ecosystem that might make it worth going down that route. But if you're just chucking some templates at the results of basic CRUD API operations or simple business logic, etc. you might not need those headaches.

IMHO go with whatever one you know and don't depend too much on any special features or framework-specific things that aren't critical. You're likely going to throw away and rewrite whatever you produce many times throughout its lifetime if it gets some legs and grows.