Cash requires a known location and/or time, and may involve the client seeing your face if face-to-face trades are made.
You still need to be local to perform the assassination, but the time and location are still vague. It's basically "somewhere the person will be at some point in the future". Makes it a lot harder to stage a sting because you can't have people set up everywhere that person will be at all times.
We're also not terribly far away from remote assassinations being possible. There was an assassination in Iran that allegedly used a computer to control a machine gun to kill someone. Combine that with a self-driving car, or a remotely operated car, and you've got a hitman mobile. Or the cheap and low-tech route, strapping explosives to drones. The cartels have already started using them, so it's not improbable that you could pilot one across the world. Pay the cartel to set up a drone and give you the credentials to control it and you don't even have to leave your home.
> It would be quite difficult to operate a ransomware operation out of, say, Belarus if you expected your victims to pay by posting you envelopes stuffed with cash.
I don't think that's really true. At the scale of money we're talking about, hiring a courier to handcuff the money to their wrist and fly across the world wouldn't be an excessive cost. The primary downside is the same; there's a known location where the money will be left and picked up.