At those income levels pretty much the only thing you’re really priced out of are nice single family homes, but I suspect that’s the same in Zurich.
You'll never pay it completely but if you can afford a mortgage you'll build equity into it and probably be able to resell it at a profit.
I have a Senior Principal position and make products you've probably read about on Ars/Verge type sites recently, at an established tech company in Berlin - for about half of those 300k. And it's not a bad deal for the region.
I earn a lot here in London, but moving to SF would be a significant bump. However, I very much value my time off.
There are also all sorts of special purpose leaves (jury duty, infant care, bereavement, etc...) that can become quite substantial.
All that being said I’ve almost never had a boss who cared about tracking my vacation too closely, and I’ve never felt pressured to not take time off when I want to, other than a half dozen critical weeks a year.
Officially, though, I (just found out that I) have 20 discretionary days per year (plus American holidays).
The "unlimited" thing became popular in California in part as an attempt on behalf of companies to avoid having to issue payouts for accrued time off to employees leaving their organizations.
I'd suggest simply being very up front and specific in interviewing and negotiations about how much time you plan to take and see what kind of reactions you get.