I was once on holiday and with US TV, and saw a few times an ad for performance enhancement for older gentlemen. The ad showed an older couple, who first are not very happy, then much happier with each other, frollicking in the long grass and disappearing off shot etc.
While that was happening, the narrator was reading in an impassioned, but also somewhat undulated voice: "side effects include headaches, blurred vision, hypertension, liver failure, paralysis and death" [I can't quite remember the list, basically it went from minor to death, as most drugs do].
For someone not at all used to serious drugs being advertised on prime-time TV, this was quite a thing to see.