For context, I have professionally deployed Linux on USB, ever since around 2004. I honestly don't care to remember all the odd issues/failures I've encountered during those 17 years. The situation certainly got better/easier with the years, but it can still be a gamble if an odd Linux distro will actually boot successfully from USB or not.
Until I discovered Ventoy, about a year or two ago, I would always be hesitant to recommend running Linux from USB, unless I knew the exact setup (or it involved someone with a decent technical skills).
Ventoy is great!!! I'd recommend everyone to at least have a look at it. It's one of the very few tools I endorse without any hesitation or reservation.
I am in no way personally involved with Ventoy, nor do I have a stake in it. I just love the tool for what it is.