The only solution is to fund basic science research directly and remove the perverse incentives, but (as an outsider) it seems America does not have the political will to do anything so bold right now.
At the end of the day though, no matter how you slice the pie of dollars, the motivation of a majority of the market is to make more money. Not to solve problems one and done. Always remember, healthcare is an industry first and foremost; cures aren't good business. Just look at what Wall Street has to say on the matter.
https://science.slashdot.org/story/18/04/14/0059236/is-curin...
So Market mechanisms don't really work unless you structure things correctly; which includes building a prize pool to pull from for each actor to further the state of the art. Try doing that in the U.S. and people will get all bent though because all that capital ends up locked away instead of lining everyone's pockets..
Which country would do the funding?