You can create a unikernel with Python - it's one of Unikraft's examples, but you won't be able to pip install modules out of the box.

Unikraft is good if you want to run untrusted code, giving a way for developers to extend functionality on your platform in Python (or JavaScript if you use Ducktape, also in their examples) - kind of like AWS Lambda and the likes. Besides the added security from running in a virtual machine, unikernels boot extremely fast. Without applying any optimizations, I have a QuickJS unikernel that boots, runs JavaScript and shuts down within 400ms (running in Windows -> VMWare -> Linux -> KVM+QEMU). This performance would be hard to get with Docker and a Linux distro.