Blinkers can mean something different at different times, depending on context, while traffic lights and signs are treated as a suggestion. Speed limits and their enforcement are non-existent (outside of expensive toll road), and lane lines aren't something that have meaning. Pedestrian traffic (or hell, animal and farm traffic) is unexpected and unexplainable, as are public transportation options (imagine giant school buses flying through roads, playing leapfrog to get in front of one another to be able to pick up the next people waiting for a ride).
The consequence of these differences for self driving cars will be a very, very difficult problem to solve unless the majority of the vehicles are self driving, which is not a solution that will happen anytime soon in Latin America.