High-dimensional characterization of post-acute sequalae of Covid-19

> We show that beyond the first 30 days of illness, people with COVID-19 exhibit higher risk of death and health resource utilization. Our high dimensional approach identifies incident sequalae in the respiratory system and several others including nervous system and neurocognitive disorders, mental health disorders, metabolic disorders, cardiovascular disorders, gastrointestinal disorders, malaise, fatigue, musculoskeletal pain, and anemia.

> To our knowledge, this is the largest post-acute COVID-19 study to date involving 73,435 non-hospitalized patients with COVID-19, and 4,990,835 controls (corresponding to 2,070,615.52 person years of follow-up), and 13,654 hospitalized patients with COVID-19, and 13,997 patients hospitalized with seasonal influenza (corresponding to 12,179.05 person years of follow-up). We leveraged the breadth and depth of the US Department of Veterans Affairs national health care databases — the largest nationally integrated healthcare delivery sys- tem in the US — to undertake a comprehensive high-dimensional com- parative approach (relative to control groups) to identify the 6-months health outcomes and clinical manifestations in COVID-19 patients who survived the first 30 days of COVID-19 illness.