There was a driver for Windows 3.x (third party, I think) which made it so Windows programs could play samples. But the computer was unresponsive during playback.

It was still semi-useful, you got the little Windows sounds playing, and if I recall correctly, there was a Windows Zeppelin game which was more fun with sporadic sound samples playing.

I upgraded my mothers 80286 PC clone with a separate ISA 8-bit MFM harddisk interface. I put in an 80486 (SX?) motherboard, which of course had IDE disk connectors. But, partly because I didn't have any spare IDE disk, and partly to make it a plug-in upgrade, I just moved over the ISA card to the 80486 motherboard and called it a day.

It was actually a very productive setup, Word 6 was really fast on that machine and the little sounds from the PC speaker driver as a nice novelty.